Validation of Ultrasensitive Mutant Huntingtin Detection in Human Cerebrospinal Fluid by Single Molecule Counting Immunoassay

BACKGROUND: The measurement of disease-relevant biomarkers has become a major component of clinical trial design, but in the absence of rigorous clinical and analytical validation of detection methodology, interpretation of results may be misleading. In Huntington’s disease (HD), measurement of the...

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Detalles Bibliográficos
Autores principales: Fodale, Valentina, Boggio, Roberto, Daldin, Manuel, Cariulo, Cristina, Spiezia, Maria Carolina, Byrne, Lauren M., Leavitt, Blair R., Wild, Edward J., Macdonald, Douglas, Weiss, Andreas, Bresciani, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757651/
https://www.ncbi.nlm.nih.gov/pubmed/29125493
http://dx.doi.org/10.3233/JHD-170269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757651/
https://www.ncbi.nlm.nih.gov/pubmed/29125493
http://dx.doi.org/10.3233/JHD-170269

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