Site-Specific Disulfide Crosslinked Nucleosomes with Enhanced Stability

We engineered nucleosome core particles (NCPs) with two site-specific cysteine crosslinks that increase the stability of the particle. The first disulfide was introduced between the two copies of H2A via an H2A-N38C point mutation, effectively crosslinking the two H2A/H2B heterodimers together to st...

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Detalles Bibliográficos
Autores principales: Frouws, Timothy D., Barth, Philip D., Richmond, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757783/
https://www.ncbi.nlm.nih.gov/pubmed/29113904
http://dx.doi.org/10.1016/j.jmb.2017.10.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757783/
https://www.ncbi.nlm.nih.gov/pubmed/29113904
http://dx.doi.org/10.1016/j.jmb.2017.10.029

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