Mechanism and regulation of the Lys6-selective deubiquitinase USP30

Damaged mitochondria undergo a specialised form of autophagy termed mitophagy, which is initiated by the ubiquitin kinase PINK1 and the E3 ligase Parkin. Ubiquitin-specific protease USP30 antagonises Parkin-mediated ubiquitination events on mitochondria and is a key negative regulator of mitophagy....

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Detalles Bibliográficos
Autores principales: Gersch, Malte, Gladkova, Christina, Schubert, Alexander F., Michel, Martin A., Maslen, Sarah, Komander, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757785/
https://www.ncbi.nlm.nih.gov/pubmed/28945249
http://dx.doi.org/10.1038/nsmb.3475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757785/
https://www.ncbi.nlm.nih.gov/pubmed/28945249
http://dx.doi.org/10.1038/nsmb.3475

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