Analyzing metabolomics data for association with genotypes using two-component Gaussian mixture distributions

Standard approaches to evaluate the impact of single nucleotide polymorphisms (SNP) on quantitative phenotypes use linear models. However, these normal-based approaches may not optimally model phenotypes which are better represented by Gaussian mixture distributions (e.g., some metabolomics data). W...

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Detalles Bibliográficos
Autores principales: Westra, Jason, Hartman, Nicholas, Lake, Bethany, Shearer, Gregory, Tintle, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757879/
https://www.ncbi.nlm.nih.gov/pubmed/29218908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757879/
https://www.ncbi.nlm.nih.gov/pubmed/29218908

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