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Cyclin D/CDK4/6 activity controls G1 length in mammalian cells

The length of the G1 phase in the cell cycle shows significant variability in different cell types and tissue types. To gain insights into the control of G1 length, we generated an E2F activity reporter that captures free E2F activity after dissociation from Rb sequestration and followed its kinetic...

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Detalles Bibliográficos
Autores principales: Dong, Peng, Zhang, Carolyn, Parker, Bao-Tran, You, Lingchong, Mathey-Prevot, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757913/
https://www.ncbi.nlm.nih.gov/pubmed/29309421
http://dx.doi.org/10.1371/journal.pone.0185637