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Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations
Inherited mitochondrial DNA (mtDNA) mutations have emerged as a common cause of human disease, with mutations occurring multiple times in the world population. The clinical presentation of three pathogenic mtDNA mutations is strongly associated with a background mtDNA haplogroup, but it is not clear...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757940/ https://www.ncbi.nlm.nih.gov/pubmed/29253894 http://dx.doi.org/10.1371/journal.pgen.1007126 |