Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes

Synthesis and scission of phosphodiester bonds in DNA and RNA regulate vital processes within the cell. Enzymes that catalyze these reactions operate mostly via the recognized two-metal-ion mechanism. Our analysis reveals that basic amino acids and monovalent cations occupy structurally conserved po...

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Detalles Bibliográficos
Autores principales: Genna, Vito, Colombo, Matteo, De Vivo, Marco, Marcia, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758106/
https://www.ncbi.nlm.nih.gov/pubmed/29225080
http://dx.doi.org/10.1016/j.str.2017.11.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758106/
https://www.ncbi.nlm.nih.gov/pubmed/29225080
http://dx.doi.org/10.1016/j.str.2017.11.008

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