Reduced neuroprotective potential of the mesenchymal stromal cell secretome with ex vivo expansion, age and progressive multiple sclerosis

BACKGROUND: Clinical trials using ex vivo expansion of autologous mesenchymal stromal cells (MSCs) are in progress for several neurological diseases including multiple sclerosis (MS). Given that environment alters MSC function, we examined whether in vitro expansion, increasing donor age and progres...

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Detalles Bibliográficos
Autores principales: Sarkar, Pamela, Redondo, Juliana, Kemp, Kevin, Ginty, Mark, Wilkins, Alastair, Scolding, Neil J., Rice, Claire M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758344/
https://www.ncbi.nlm.nih.gov/pubmed/28917625
http://dx.doi.org/10.1016/j.jcyt.2017.08.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758344/
https://www.ncbi.nlm.nih.gov/pubmed/28917625
http://dx.doi.org/10.1016/j.jcyt.2017.08.007

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