Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their relevance in addiction is not known. The existence of the D1-D2 heteromer in the striatum of rat and monkey was established using in situ P...

Descripción completa

Detalles Bibliográficos
Autores principales: Hasbi, Ahmed, Perreault, Melissa L., Shen, Maurice Y. F., Fan, Theresa, Nguyen, Tuan, Alijaniaram, Mohammed, Banasikowski, Tomek J., Grace, Anthony A., O'Dowd, Brian F., Fletcher, Paul J., George, Susan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758537/
https://www.ncbi.nlm.nih.gov/pubmed/29354053
http://dx.doi.org/10.3389/fphar.2017.00924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758537/
https://www.ncbi.nlm.nih.gov/pubmed/29354053
http://dx.doi.org/10.3389/fphar.2017.00924

Ejemplares similares