Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

The tumor suppressor gene TP53 is inactivated by mutation in a large fraction of human tumors. Around 10% of TP53 mutations are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional p53 protein. Aminoglycosides G418 (geneticin) a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Meiqiongzi, Heldin, Angelos, Palomar-Siles, Mireia, Öhlin, Susanne, Bykov, Vladimir J. N., Wiman, Klas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758538/
https://www.ncbi.nlm.nih.gov/pubmed/29354595
http://dx.doi.org/10.3389/fonc.2017.00323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758538/
https://www.ncbi.nlm.nih.gov/pubmed/29354595
http://dx.doi.org/10.3389/fonc.2017.00323

Ejemplares similares