Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica

Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG), an antibody that selectively binds to the aquaporin-4. Here, we established a localized NMO model by injecting NMO-IgG into the spinal cord, and assessed the efficacy of treating its NMO-like symptoms...

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Autores principales: Harada, Kana, Fujita, Yuki, Okuno, Tatsusada, Tanabe, Shogo, Koyama, Yoshihisa, Mochizuki, Hideki, Yamashita, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758562/
https://www.ncbi.nlm.nih.gov/pubmed/29311561
http://dx.doi.org/10.1038/s41598-017-18362-2
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author Harada, Kana
Fujita, Yuki
Okuno, Tatsusada
Tanabe, Shogo
Koyama, Yoshihisa
Mochizuki, Hideki
Yamashita, Toshihide
author_facet Harada, Kana
Fujita, Yuki
Okuno, Tatsusada
Tanabe, Shogo
Koyama, Yoshihisa
Mochizuki, Hideki
Yamashita, Toshihide
author_sort Harada, Kana
collection PubMed
description Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG), an antibody that selectively binds to the aquaporin-4. Here, we established a localized NMO model by injecting NMO-IgG into the spinal cord, and assessed the efficacy of treating its NMO-like symptoms by blocking repulsive guidance molecule-a (RGMa), an axon growth inhibitor. The model showed pathological features consistent with NMO. Systemic administration of humanized monoclonal anti-RGMa antibody delayed the onset and attenuated the severity of clinical symptoms. Further, it preserved astrocytes and reduced inflammatory-cell infiltration and axonal damage, suggesting that targeting RGMa is effective in treating NMO.
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spelling pubmed-57585622018-01-10 Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica Harada, Kana Fujita, Yuki Okuno, Tatsusada Tanabe, Shogo Koyama, Yoshihisa Mochizuki, Hideki Yamashita, Toshihide Sci Rep Article Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG), an antibody that selectively binds to the aquaporin-4. Here, we established a localized NMO model by injecting NMO-IgG into the spinal cord, and assessed the efficacy of treating its NMO-like symptoms by blocking repulsive guidance molecule-a (RGMa), an axon growth inhibitor. The model showed pathological features consistent with NMO. Systemic administration of humanized monoclonal anti-RGMa antibody delayed the onset and attenuated the severity of clinical symptoms. Further, it preserved astrocytes and reduced inflammatory-cell infiltration and axonal damage, suggesting that targeting RGMa is effective in treating NMO. Nature Publishing Group UK 2018-01-08 /pmc/articles/PMC5758562/ /pubmed/29311561 http://dx.doi.org/10.1038/s41598-017-18362-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Harada, Kana
Fujita, Yuki
Okuno, Tatsusada
Tanabe, Shogo
Koyama, Yoshihisa
Mochizuki, Hideki
Yamashita, Toshihide
Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica
title Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica
title_full Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica
title_fullStr Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica
title_full_unstemmed Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica
title_short Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica
title_sort inhibition of rgma alleviates symptoms in a rat model of neuromyelitis optica
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758562/
https://www.ncbi.nlm.nih.gov/pubmed/29311561
http://dx.doi.org/10.1038/s41598-017-18362-2
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