Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A(2A) Receptor crystals

Here we report an efficient method to generate multiple co-structures of the A(2A) G protein-coupled receptor (GPCR) with small-molecules from a single preparation of a thermostabilised receptor crystallised in Lipidic Cubic Phase (LCP). Receptor crystallisation is achieved following purification us...

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Detalles Bibliográficos
Autores principales: Rucktooa, Prakash, Cheng, Robert K. Y., Segala, Elena, Geng, Tian, Errey, James C., Brown, Giles A., Cooke, Robert M., Marshall, Fiona H., Doré, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758569/
https://www.ncbi.nlm.nih.gov/pubmed/29311713
http://dx.doi.org/10.1038/s41598-017-18570-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758569/
https://www.ncbi.nlm.nih.gov/pubmed/29311713
http://dx.doi.org/10.1038/s41598-017-18570-w

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