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Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing

Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in pharmacological safety testing. Through the injection of co...

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Detalles Bibliográficos
Autores principales: Ortega, Francis A., Grandi, Eleonora, Krogh-Madsen, Trine, Christini, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758594/
https://www.ncbi.nlm.nih.gov/pubmed/29354069
http://dx.doi.org/10.3389/fphys.2017.01099