Combined shRNA over CRISPR/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism

Inhibition of genes is a powerful approach to study their function. While RNA interference is a widely used method to achieve this goal, mounting evidence indicates that such an approach is prone to off-target effects. An alternative approach to gene function inhibition is genetic mutation, such as...

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Detalles Bibliográficos
Autores principales: Peretz, Liat, Besser, Elazar, Hajbi, Renana, Casden, Natania, Ziv, Dan, Kronenberg, Nechama, Gigi, Liat Ben, Sweetat, Sahar, Khawaled, Saleh, Aqeilan, Rami, Behar, Oded
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758708/
https://www.ncbi.nlm.nih.gov/pubmed/29311693
http://dx.doi.org/10.1038/s41598-017-18551-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758708/
https://www.ncbi.nlm.nih.gov/pubmed/29311693
http://dx.doi.org/10.1038/s41598-017-18551-z

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