Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency

Aging imposes a barrier to somatic cell reprogramming through poorly understood mechanisms. Here, we report that fibroblasts from old mice express higher levels of Zeb2, a transcription factor that activates epithelial-to-mesenchymal transition. Synthesis of Zeb2 protein is controlled by a natural a...

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Detalles Bibliográficos
Autores principales: Bernardes de Jesus, Bruno, Marinho, Sérgio Pires, Barros, Sara, Sousa-Franco, António, Alves-Vale, Catarina, Carvalho, Tânia, Carmo-Fonseca, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758807/
https://www.ncbi.nlm.nih.gov/pubmed/29311544
http://dx.doi.org/10.1038/s41467-017-01921-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758807/
https://www.ncbi.nlm.nih.gov/pubmed/29311544
http://dx.doi.org/10.1038/s41467-017-01921-6

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