Characterization of the interactions between inhibitor-1 and recombinant PP1 by NMR spectroscopy

Inhibitor-1 is converted into a potent inhibitor of native protein phosphatase-1 (PP1) when Thr35 is phosphorylated by cAMP-dependent protein kinase (PKA). However, PKA-phosphorylated form of inhibitor-1 displayed a weak activity in inhibition of recombinant PP1. The mechanism for the impaired activ...

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Detalles Bibliográficos
Autores principales: Liang, Chu-Ting, Lin, Yu-Shan, Huang, Yi-Choang, Huang, Hsien-Lu, Yang, Jia-Qian, Wu, Tsung-Hsien, Chang, Chi-Fon, Huang, Shing-Jong, Huang, Hsien-Bin, Lin, Ta-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758809/
https://www.ncbi.nlm.nih.gov/pubmed/29311589
http://dx.doi.org/10.1038/s41598-017-18383-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758809/
https://www.ncbi.nlm.nih.gov/pubmed/29311589
http://dx.doi.org/10.1038/s41598-017-18383-x

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