A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair host resistance to intracellular bacteria in mice. However, the precise role of type I IFN signaling in bacterial infection in humans is unclear. Here, we show that genetic variation in the human IFNAR1 ge...

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Detalles Bibliográficos
Autores principales: Zhang, Guoliang, deWeerd, Nicole A., Stifter, Sebastian A., Liu, Lei, Zhou, Boping, Wang, Wenfei, Zhou, Yiping, Ying, Binwu, Hu, Xuejiao, Matthews, Antony Y., Ellis, Magda, Triccas, James A., Hertzog, Paul J., Britton, Warwick J., Chen, Xinchun, Feng, Carl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758831/
https://www.ncbi.nlm.nih.gov/pubmed/29311663
http://dx.doi.org/10.1038/s41467-017-02611-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758831/
https://www.ncbi.nlm.nih.gov/pubmed/29311663
http://dx.doi.org/10.1038/s41467-017-02611-z

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