Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria

Mycobacterium tuberculosis (Mtb) encodes two CRP/FNR family transcription factors (TF) that contribute to virulence, Cmr (Rv1675c) and CRP(Mt) (Rv3676). Prior studies identified distinct chromosomal binding profiles for each TF despite their recognizing overlapping DNA motifs. The present study show...

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Detalles Bibliográficos
Autores principales: Ranganathan, Sridevi, Cheung, Jonah, Cassidy, Michael, Ginter, Christopher, Pata, Janice D, McDonough, Kathleen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758884/
https://www.ncbi.nlm.nih.gov/pubmed/29165665
http://dx.doi.org/10.1093/nar/gkx1148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758884/
https://www.ncbi.nlm.nih.gov/pubmed/29165665
http://dx.doi.org/10.1093/nar/gkx1148

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