Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy

Gene therapy by engineering patient's own blood cells to confer HIV resistance can potentially lead to a functional cure for AIDS. Toward this goal, we have previously developed an anti-HIV lentivirus vector that deploys a combination of shRNA, ribozyme and RNA decoy. To further improve this th...

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Detalles Bibliográficos
Autores principales: Pang, Ka Ming, Castanotto, Daniela, Li, Haitang, Scherer, Lisa, Rossi, John J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758892/
https://www.ncbi.nlm.nih.gov/pubmed/29077949
http://dx.doi.org/10.1093/nar/gkx980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758892/
https://www.ncbi.nlm.nih.gov/pubmed/29077949
http://dx.doi.org/10.1093/nar/gkx980

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