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Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy
Gene therapy by engineering patient's own blood cells to confer HIV resistance can potentially lead to a functional cure for AIDS. Toward this goal, we have previously developed an anti-HIV lentivirus vector that deploys a combination of shRNA, ribozyme and RNA decoy. To further improve this th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758892/ https://www.ncbi.nlm.nih.gov/pubmed/29077949 http://dx.doi.org/10.1093/nar/gkx980 |