Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs

RNase H1-dependent antisense oligonucleotides (ASOs) can degrade complementary RNAs in both the nucleus and the cytoplasm. Since cytoplasmic mRNAs are actively engaged in translation, ASO activity may thus be affected by translating ribosomes that scan the mRNAs. Here we show that mRNAs associated w...

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Detalles Bibliográficos
Autores principales: Liang, Xue-Hai, Nichols, Joshua G, Sun, Hong, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758896/
https://www.ncbi.nlm.nih.gov/pubmed/29165591
http://dx.doi.org/10.1093/nar/gkx1174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758896/
https://www.ncbi.nlm.nih.gov/pubmed/29165591
http://dx.doi.org/10.1093/nar/gkx1174

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