Designer tRNAs for efficient incorporation of non-canonical amino acids by the pyrrolysine system in mammalian cells

The pyrrolysyl-tRNA synthetase/tRNA(Pyl) pair is the most versatile and widespread system for the incorporation of non-canonical amino acids (ncAAs) into proteins in mammalian cells. However, low yields of ncAA incorporation severely limit its applicability to relevant biological targets. Here, we g...

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Detalles Bibliográficos
Autores principales: Serfling, Robert, Lorenz, Christian, Etzel, Maja, Schicht, Gerda, Böttke, Thore, Mörl, Mario, Coin, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758916/
https://www.ncbi.nlm.nih.gov/pubmed/29177436
http://dx.doi.org/10.1093/nar/gkx1156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758916/
https://www.ncbi.nlm.nih.gov/pubmed/29177436
http://dx.doi.org/10.1093/nar/gkx1156

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