The tankyrase inhibitor G007-LK inhibits small intestine LGR5(+) stem cell proliferation without altering tissue morphology

BACKGROUND: The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase enzymes tankyrase1 and 2. LGR5 is a known WNT pathway target gene and marker o...

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Detalles Bibliográficos
Autores principales: Norum, Jens Henrik, Skarpen, Ellen, Brech, Andreas, Kuiper, Raoul, Waaler, Jo, Krauss, Stefan, Sørlie, Therese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759193/
https://www.ncbi.nlm.nih.gov/pubmed/29316982
http://dx.doi.org/10.1186/s40659-017-0151-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759193/
https://www.ncbi.nlm.nih.gov/pubmed/29316982
http://dx.doi.org/10.1186/s40659-017-0151-6

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