α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

BACKGROUND: Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susceptibilit...

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Detalles Bibliográficos
Autores principales: Yun, Seung Pil, Kim, Donghoon, Kim, Sangjune, Kim, SangMin, Karuppagounder, Senthilkumar S., Kwon, Seung-Hwan, Lee, Saebom, Kam, Tae-In, Lee, Suhyun, Ham, Sangwoo, Park, Jae Hong, Dawson, Valina L., Dawson, Ted M., Lee, Yunjong, Ko, Han Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759291/
https://www.ncbi.nlm.nih.gov/pubmed/29310663
http://dx.doi.org/10.1186/s13024-017-0233-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759291/
https://www.ncbi.nlm.nih.gov/pubmed/29310663
http://dx.doi.org/10.1186/s13024-017-0233-5

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