Population Pharmacokinetics of Fosdagrocorat (PF‐04171327), a Dissociated Glucocorticoid Receptor Agonist, in Patients With Rheumatoid Arthritis

Dissociated agonists of the glucocorticoid receptor (DAGRs) show similar antiinflammatory effects but improved tolerability compared with standard glucocorticoid receptor (GR) agonists. The prodrug fosdagrocorat (PF‐04171327), with active DAGR metabolite PF‐00251802 (Metabolite‐1), is postulated to...

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Detalles Bibliográficos
Autores principales: Weatherley, Barry, McFadyen, Lynn, Tammara, Brinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759734/
https://www.ncbi.nlm.nih.gov/pubmed/29106053
http://dx.doi.org/10.1111/cts.12515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759734/
https://www.ncbi.nlm.nih.gov/pubmed/29106053
http://dx.doi.org/10.1111/cts.12515

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