Cargando…

WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms

BACKGROUND: Targeting the endocannabinoid system has emerged as an effective strategy for the treatment of inflammatory and neurological diseases. Unlike the inhibition of the principal 2-arachidonyl glycerol (2-AG) hydrolytic enzyme monoacylglycerol lipase (MAGL), which leads to 2-AG overload and c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Jie, Jones, Melissa, Tanaka, Mikiei, Selvaraj, Prabhuanand, Symes, Aviva J., Cox, Brian, Zhang, Yumin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759843/ https://www.ncbi.nlm.nih.gov/pubmed/29310667 http://dx.doi.org/10.1186/s12974-017-1045-9

Ejemplares similares

WWL70 attenuates PGE(2) production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism
por: Tanaka, Mikiei, et al.
Publicado: (2017)

Therapeutic Effect of the Substrate-Selective COX-2 Inhibitor IMMA in the Animal Model of Chronic Constriction Injury
por: Jones, Melissa, et al.
Publicado: (2018)

The Novel Monoacylglycerol Lipase Inhibitor MJN110 Suppresses Neuroinflammation, Normalizes Synaptic Composition and Improves Behavioral Performance in the Repetitive Traumatic Brain Injury Mouse Model
por: Selvaraj, Prabhuanand, et al.
Publicado: (2021)

Therapeutic Effects of Combined Treatment with the AEA Hydrolysis Inhibitor PF04457845 and the Substrate Selective COX-2 Inhibitor LM4131 in the Mouse Model of Neuropathic Pain
por: Wen, Jie, et al.
Publicado: (2023)

Targeting the endogenous cannabinoid system to treat neuropathic pain
por: Lau, Benjamin K., et al.
Publicado: (2014)

Recent data on cannabinoids and their pharmacological implications in neuropathic pain
por: Oana, Andreia Coman, et al.
Publicado: (2008)

Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain
por: Casey, Sherelle L., et al.
Publicado: (2018)

Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain
por: Hsu, Hsin-Cheng, et al.
Publicado: (2014)

Sodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats
por: Lin, Jian-qing, et al.
Publicado: (2014)

Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury
por: Chen, Qin-Yi, et al.
Publicado: (2019)

Protective role of neuronal and lymphoid cannabinoid CB(2) receptors in neuropathic pain
por: Cabañero, David, et al.
Publicado: (2020)

Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain
por: Hossain, Mohammad Zakir, et al.
Publicado: (2020)

Ninjin'yoeito Alleviates Neuropathic Pain Induced by Chronic Constriction Injury in Rats
por: Takemoto, Risa, et al.
Publicado: (2021)

Sanguinarine Attenuates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
por: Li, Ping, et al.
Publicado: (2021)

Preclinical Studies of Posttraumatic Headache and the Potential Therapeutics
por: Tanaka, Mikiei, et al.
Publicado: (2022)

Curcumin Attenuates Mechanical and Thermal Hyperalgesia in Chronic Constrictive Injury Model of Neuropathic Pain
por: Di, Yu Xiang, et al.
Publicado: (2014)

The Effect of Ethanolic Extract of Lippia Citriodora on Rats with Chronic Constriction Injury of Neuropathic pain
por: Amin, Bahareh, et al.
Publicado: (2018)

Effect of biotin supplementation on neuropathic pain induced by chronic constriction of the sciatic nerve in the rat
por: Abed, Ali-Reza, et al.
Publicado: (2021)

R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids
por: Bishay, Philipp, et al.
Publicado: (2010)

Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats
por: Vafaei, Abbas Ali, et al.
Publicado: (2020)

Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
por: Toth, Cory C, et al.
Publicado: (2010)

Endocannabinoid Modulation of Microglial Phenotypes in Neuropathology
por: Tanaka, Mikiei, et al.
Publicado: (2020)

Behavior of neuropathic pain in mice following chronic constriction injury comparing silk and catgut ligatures
por: van der Wal, Selina, et al.
Publicado: (2015)

Comparison of the Effects of Zonisamide, Ethosuximide and Pregabalin in the Chronic Constriction Injury Induced Neuropathic Pain in Rats
por: Goyal, S, et al.
Publicado: (2015)

Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats
por: Zhou, Jianyu, et al.
Publicado: (2016)

TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice
por: Piao, Yibo, et al.
Publicado: (2018)

Effect of Chrysin on Mechanical Hyperalgesia in Chronic Constriction Injury-Induced Neuropathic Pain in Rat Model
por: Rayiti, Rama Krishna, et al.
Publicado: (2020)

Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats
por: Bakare, Ahmed Olalekan, et al.
Publicado: (2020)

Fumagillin Attenuates Spinal Angiogenesis, Neuroinflammation, and Pain in Neuropathic Rats after Chronic Constriction Injury
por: Wen, Zhi-Hong, et al.
Publicado: (2021)

Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats
por: Foudah, Ahmed I., et al.
Publicado: (2022)

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
por: Xiong, Wei, et al.
Publicado: (2012)

Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2
por: Yang, Longhe, et al.
Publicado: (2014)

Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
por: Campos, Raquel Maria P., et al.
Publicado: (2021)

Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice
por: Liu, Shufeng, et al.
Publicado: (2022)

Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α
por: Onodera, Yoshiko, et al.
Publicado: (2017)

Effect of the spinal apelin-APJ system on the pathogenesis of chronic constriction injury-induced neuropathic pain in rats
por: Xiong, Qingming, et al.
Publicado: (2017)

Exploring the role and mechanisms of diallyl trisulfide and diallyl disulfide in chronic constriction-induced neuropathic pain in rats
por: Wang, Gang, et al.
Publicado: (2020)

Investigation of Neuroprotective Effects of Erythropoietin on Chronic Neuropathic Pain in a Chronic Constriction Injury Rat Model
por: Zhang, Kai, et al.
Publicado: (2020)

RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling
por: He, Na, et al.
Publicado: (2021)

The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain
por: Cheng, Kuang-I, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_455v1ukioavkvdn7a9vimmbrlo