Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies

Rare variants of major effect play an important role in human complex diseases and can be discovered by sequencing-based genome-wide association studies. Here, we introduce an integrated approach that combines the rare variant association test with gene network and phenotype information to identify...

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Detalles Bibliográficos
Autores principales: Lin, Jhih-Rong, Zhang, Quanwei, Cai, Ying, Morrow, Bernice E., Zhang, Zhengdong D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760082/
https://www.ncbi.nlm.nih.gov/pubmed/29281626
http://dx.doi.org/10.1371/journal.pgen.1007142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760082/
https://www.ncbi.nlm.nih.gov/pubmed/29281626
http://dx.doi.org/10.1371/journal.pgen.1007142

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