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System identification of signaling dependent gene expression with different time-scale data

Cells decode information of signaling activation at a scale of tens of minutes by downstream gene expression with a scale of hours to days, leading to cell fate decisions such as cell differentiation. However, no system identification method with such different time scales exists. Here we used compr...

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Detalles Bibliográficos
Autores principales: Tsuchiya, Takaho, Fujii, Masashi, Matsuda, Naoki, Kunida, Katsuyuki, Uda, Shinsuke, Kubota, Hiroyuki, Konishi, Katsumi, Kuroda, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760096/
https://www.ncbi.nlm.nih.gov/pubmed/29281625
http://dx.doi.org/10.1371/journal.pcbi.1005913