To what extent do structural changes in catalytic metal sites affect enzyme function?

About half of known enzymatic reactions involve metals. Enzymes belonging to the same superfamily often evolve to catalyze different reactions on the same structural scaffold. The work presented here investigates how functional differentiation, within superfamilies that contain metalloenzymes, relat...

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Detalles Bibliográficos
Autores principales: Valasatava, Yana, Rosato, Antonio, Furnham, Nicholas, Thornton, Janet M., Andreini, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760197/
https://www.ncbi.nlm.nih.gov/pubmed/29161638
http://dx.doi.org/10.1016/j.jinorgbio.2017.11.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760197/
https://www.ncbi.nlm.nih.gov/pubmed/29161638
http://dx.doi.org/10.1016/j.jinorgbio.2017.11.002

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