Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine(437)

Cdk5 is a post-mitotic kinase with complex roles in maintaining neuronal health. The various mechanisms by which Cdk5 inhibits and promotes neurodegeneration are still poorly understood. Here, we show that in Drosophila melanogaster Cdk5 regulates basal autophagy, a key mechanism suppressing neurode...

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Detalles Bibliográficos
Autores principales: Nandi, Nilay, Tyra, Lauren K, Stenesen, Drew, Krämer, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760206/
https://www.ncbi.nlm.nih.gov/pubmed/29227247
http://dx.doi.org/10.7554/eLife.30760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760206/
https://www.ncbi.nlm.nih.gov/pubmed/29227247
http://dx.doi.org/10.7554/eLife.30760

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