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Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma
Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. In terms of antitumor immunity, CD1d-dependent natural killer T (NKT...
Autores principales: | Liu, Jianyun, Gallo, Richard M., Khan, Masood A., Renukaradhya, Gourapura J., Brutkiewicz, Randy R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760513/ https://www.ncbi.nlm.nih.gov/pubmed/29354122 http://dx.doi.org/10.3389/fimmu.2017.01901 |
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