Cargando…

Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae

To assess drug-induced pro-arrhythmic risk, especially Torsades de Pointe (TdP), new models have been proposed, such as in-silico modeling of ventricular action potential (AP) and stem cell-derived cardiomyocytes (SC-CMs). Previously we evaluated the electrophysiological profile of 15 reference drug...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qu, Yusheng, Page, Guy, Abi-Gerges, Najah, Miller, Paul E., Ghetti, Andre, Vargas, Hugo M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760531/ https://www.ncbi.nlm.nih.gov/pubmed/29354071 http://dx.doi.org/10.3389/fphys.2017.01109

Ejemplares similares

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability
por: Britton, Oliver J., et al.
Publicado: (2017)

Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk
por: Nguyen, Nathalie, et al.
Publicado: (2017)

Multiparametric Mechanistic Profiling of Inotropic Drugs in Adult Human Primary Cardiomyocytes
por: Abi-Gerges, Najah, et al.
Publicado: (2020)

Disruption of Transverse-Tubules Eliminates the Slow Force Response to Stretch in Isolated Rat Trabeculae
por: Power, Amelia, et al.
Publicado: (2020)

Is CRT pro-arrhythmic? A comparative analysis of the occurrence of ventricular arrhythmias between patients implanted with CRTs and ICDs
por: Gopalamurugan, A. B., et al.
Publicado: (2014)

Quantification of left ventricular trabeculae using fractal analysis
por: Captur, Gabriella, et al.
Publicado: (2013)

Autonomic Neuromodulation for Preventing and Treating Ventricular Arrhythmias
por: Lai, Yanqiu, et al.
Publicado: (2019)

Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia
por: Funken, Maximilian, et al.
Publicado: (2019)

The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias
por: Chen, Mingxian, et al.
Publicado: (2020)

Trabeculae carneae as models of the ventricular walls: implications for the delivery of oxygen
por: Goo, Soyeon, et al.
Publicado: (2009)

Performance and Robustness Testing of a Non-Invasive Mapping System for Ventricular Arrhythmias
por: Lesina, Krista, et al.
Publicado: (2022)

Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart
por: Ton, Anh Tuan, et al.
Publicado: (2021)

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias
por: Dhein, Stefan, et al.
Publicado: (2014)

Reduced mechanical efficiency in left‐ventricular trabeculae of the spontaneously hypertensive rat
por: Han, June‐Chiew, et al.
Publicado: (2014)

Development of the ventricular myocardial trabeculae in Scyliorhinus canicula (Chondrichthyes): evolutionary implications
por: López-Unzu, Miguel A., et al.
Publicado: (2020)

Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline
por: Dashwood, Alexander, et al.
Publicado: (2021)

Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
por: Doste, Ruben, et al.
Publicado: (2022)

Detection of Life Threatening Ventricular Arrhythmia Using Digital Taylor Fourier Transform
por: Tripathy, Rajesh K., et al.
Publicado: (2018)

Imbalance of autonomic nervous systems involved in ventricular arrhythmia after splenectomy in dogs
por: PASTARAPATEE, Nuttika, et al.
Publicado: (2017)

Quantifying left ventricular trabeculae function – application of image-based fractal analysis
por: Moore, Brandon, et al.
Publicado: (2013)

3D printed trabeculae conditionally reproduce the mechanical properties of the actual trabeculae - A preliminary study
por: Zheng, Liqin, et al.
Publicado: (2022)

AAV9-Mediated Overexpression of TRPM4 Increases the Incidence of Stress-Induced Ventricular Arrhythmias in Mice
por: Pironet, Andy, et al.
Publicado: (2019)

Electrocardiography is Useful to Predict Postoperative Ventricular Arrhythmia in Patients Undergoing Cardiac Surgery: A Retrospective Study
por: Li, Weichao, et al.
Publicado: (2022)

Histology and Morphology of the Brain Subarachnoid Trabeculae
por: Saboori, Parisa, et al.
Publicado: (2015)

Morphogenesis of myocardial trabeculae in the mouse embryo
por: Captur, Gabriella, et al.
Publicado: (2016)

Quantification of left ventricular trabeculae using cardiac magnetic resonance imaging for the diagnosis of left ventricular non-compaction
por: Choi, Yeonu, et al.
Publicado: (2015)

Pro-Arrhythmic Ventricular Remodeling Is Associated With Increased Respiratory and Low-Frequency Oscillations of Monophasic Action Potential Duration in the Chronic Atrioventricular Block Dog Model
por: Sprenkeler, David Jaap, et al.
Publicado: (2019)

Supplementation of Lipoic Acid, Zinc and Clopidogrel Reduces Mortality Rate and Incidence of Ventricular Arrhythmia in Experimental Myocardial Infarction
por: Abdel-Hady, Enas, et al.
Publicado: (2021)

Analysis of 24-h Rhythm in Ventricular Repolarization Identifies QT Diurnality As a Novel Clinical Parameter Associated with Previous Ventricular Arrhythmias in Heart Failure Patients
por: Du Pre, Bastiaan C., et al.
Publicado: (2017)

Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias
por: Karagueuzian, Hrayr S., et al.
Publicado: (2013)

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities
por: Trovato, Cristian, et al.
Publicado: (2020)

Streptozotocin-induced diabetes prolongs twitch duration without affecting the energetics of isolated ventricular trabeculae
por: Han, June-Chiew, et al.
Publicado: (2014)

Platelets and Cardiac Arrhythmia
por: de Jong, Jonas S. S. G., et al.
Publicado: (2010)

Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach
por: Trayanova, Natalia A., et al.
Publicado: (2014)

No Association Between T-peak to T-end Interval on the Resting ECG and Long-Term Incidence of Ventricular Arrhythmias Triggering ICD Interventions
por: Michalek, Peter, et al.
Publicado: (2020)

Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias
por: Dura, Miroslav, et al.
Publicado: (2014)

Spontaneous and propagated contractions in rat cardiac trabeculae
Publicado: (1989)

Morphogenetic aspects of the septomarginal trabecula in the human heart
por: Kosiński, Adam, et al.
Publicado: (2010)

Multiscale modeling of twitch contractions in cardiac trabeculae
por: Mijailovich, Srboljub M., et al.
Publicado: (2021)

Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_sgeuf8eeivtqn71amqj08kjfqo