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TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder

Both TRPV1 and P2X receptors present on bladder sensory nerve fibres have been implicated in mechanosensation during bladder filling. The aim of this study was to determine possible interactions between these receptors in modulating afferent nerve activity. In wildtype (TRPV1(+/+)) and TRPV1 knockou...

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Detalles Bibliográficos
Autores principales: Grundy, Luke, Daly, Donna M., Chapple, Christopher, Grundy, David, Chess-Williams, Russ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760578/
https://www.ncbi.nlm.nih.gov/pubmed/29317663
http://dx.doi.org/10.1038/s41598-017-18136-w