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Bi-valent polysaccharides of Vi capsular and O9 O-antigen in attenuated Salmonella Typhimurium induce strong immune responses against these two antigens

Salmonella Typhi is the causative agent of typhoid fever in humans, responsible for approximately 21 million infections and 222,000 deaths globally each year. The current licensed vaccines provide moderate protection to recipients aged >2 years. Prior work on typhoid vaccines has focused on injec...

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Detalles Bibliográficos
Autores principales: Li, Pei, Liu, Qing, Luo, Hongyan, Liang, Kang, Han, Yue, Roland, Kenneth L., Curtiss, Roy, Kong, Qingke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760606/
https://www.ncbi.nlm.nih.gov/pubmed/29354293
http://dx.doi.org/10.1038/s41541-017-0041-5