Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signatures

Genome-wide identification of all target proteins of drug candidate compounds is a challenging issue in drug discovery. Moreover, emerging phenotypic effects, including therapeutic and adverse effects, are heavily dependent on the inhibition or activation of target proteins. Here we propose a novel...

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Detalles Bibliográficos
Autores principales: Sawada, Ryusuke, Iwata, Michio, Tabei, Yasuo, Yamato, Haruka, Yamanishi, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760621/
https://www.ncbi.nlm.nih.gov/pubmed/29317676
http://dx.doi.org/10.1038/s41598-017-18315-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760621/
https://www.ncbi.nlm.nih.gov/pubmed/29317676
http://dx.doi.org/10.1038/s41598-017-18315-9

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