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Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signatures
Genome-wide identification of all target proteins of drug candidate compounds is a challenging issue in drug discovery. Moreover, emerging phenotypic effects, including therapeutic and adverse effects, are heavily dependent on the inhibition or activation of target proteins. Here we propose a novel...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760621/ https://www.ncbi.nlm.nih.gov/pubmed/29317676 http://dx.doi.org/10.1038/s41598-017-18315-9 |