Loss of the Mitochondrial Fatty Acid β-Oxidation Protein Medium-Chain Acyl-Coenzyme A Dehydrogenase Disrupts Oxidative Phosphorylation Protein Complex Stability and Function

Medium-chain acyl-Coenzyme A dehydrogenase (MCAD) is involved in the initial step of mitochondrial fatty acid β-oxidation (FAO). Loss of function results in MCAD deficiency, a disorder that usually presents in childhood with hypoketotic hypoglycemia, vomiting and lethargy. While the disruption of mi...

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Detalles Bibliográficos
Autores principales: Lim, Sze Chern, Tajika, Makiko, Shimura, Masaru, Carey, Kirstyn T., Stroud, David A., Murayama, Kei, Ohtake, Akira, McKenzie, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760697/
https://www.ncbi.nlm.nih.gov/pubmed/29317722
http://dx.doi.org/10.1038/s41598-017-18530-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760697/
https://www.ncbi.nlm.nih.gov/pubmed/29317722
http://dx.doi.org/10.1038/s41598-017-18530-4

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