Selective targeting of Scn8a prevents seizure development in a mouse model of mesial temporal lobe epilepsy

We previously found that genetic mutants with reduced expression or activity of Scn8a are resistant to induced seizures and that co-segregation of a mutant Scn8a allele can increase survival and seizure resistance of Scn1a mutant mice. In contrast, Scn8a expression is increased in the hippocampus fo...

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Detalles Bibliográficos
Autores principales: Wong, Jennifer C., Makinson, Christopher D., Lamar, Tyra, Cheng, Qi, Wingard, Jeffrey C., Terwilliger, Ernest F., Escayg, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760706/
https://www.ncbi.nlm.nih.gov/pubmed/29317669
http://dx.doi.org/10.1038/s41598-017-17786-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760706/
https://www.ncbi.nlm.nih.gov/pubmed/29317669
http://dx.doi.org/10.1038/s41598-017-17786-0

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