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Selective targeting of Scn8a prevents seizure development in a mouse model of mesial temporal lobe epilepsy
We previously found that genetic mutants with reduced expression or activity of Scn8a are resistant to induced seizures and that co-segregation of a mutant Scn8a allele can increase survival and seizure resistance of Scn1a mutant mice. In contrast, Scn8a expression is increased in the hippocampus fo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760706/ https://www.ncbi.nlm.nih.gov/pubmed/29317669 http://dx.doi.org/10.1038/s41598-017-17786-0 |