The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

The production of antibiotics by microbes in the environment and their use in medicine and agriculture select for existing and emerging resistance. To address this inevitability, prudent development of antibiotic drugs requires careful consideration of resistance evolution. Here, we identify the mol...

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Detalles Bibliográficos
Autores principales: Pawlowski, Andrew C., Stogios, Peter J., Koteva, Kalinka, Skarina, Tatiana, Evdokimova, Elena, Savchenko, Alexei, Wright, Gerard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760710/
https://www.ncbi.nlm.nih.gov/pubmed/29317655
http://dx.doi.org/10.1038/s41467-017-02680-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760710/
https://www.ncbi.nlm.nih.gov/pubmed/29317655
http://dx.doi.org/10.1038/s41467-017-02680-0

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