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Targeting RNA G‐quadruplexes as new treatment strategy for C9orf72 ALS/FTD
The recent discovery of a pathogenic expansion of a (GGGGCC)(n) repeat in the C9orf72 gene in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) led to a burst of mechanistic discoveries. In this issue, Simone et al (2018) describe novel compounds targeting the G‐quadruplex (G‐Q)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760851/ https://www.ncbi.nlm.nih.gov/pubmed/29175945 http://dx.doi.org/10.15252/emmm.201708572 |