Ceruloplasmin replacement therapy ameliorates neurological symptoms in a preclinical model of aceruloplasminemia

Aceruloplasminemia is a monogenic disease caused by mutations in the ceruloplasmin gene that result in loss of protein ferroxidase activity. Ceruloplasmin plays a role in iron homeostasis, and its activity impairment leads to iron accumulation in liver, pancreas, and brain. Iron deposition promotes...

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Detalles Bibliográficos
Autores principales: Zanardi, Alan, Conti, Antonio, Cremonesi, Marco, D'Adamo, Patrizia, Gilberti, Enrica, Apostoli, Pietro, Cannistraci, Carlo Vittorio, Piperno, Alberto, David, Samuel, Alessio, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760856/
https://www.ncbi.nlm.nih.gov/pubmed/29183916
http://dx.doi.org/10.15252/emmm.201708361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760856/
https://www.ncbi.nlm.nih.gov/pubmed/29183916
http://dx.doi.org/10.15252/emmm.201708361

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