Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LC–MS/MS: Method development, validation and application to pharmacokinetics

A rapid and sensitive method based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) for the determination of a novel anticoagulant peptide bivalirudin in human plasma has been developed and validated. Plasma samples were precipitated protein with acetonitrile and re-extracted with dichlo...

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Detalles Bibliográficos
Autores principales: Li, Xiao-Jiao, Sun, Yan-Tong, Yin, Lei, Zhang, Xue-Ju, Yang, Yan, Paul Fawcett, J., Cui, Yi-Min, Gu, Jing-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760933/
https://www.ncbi.nlm.nih.gov/pubmed/29403790
http://dx.doi.org/10.1016/j.jpha.2012.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760933/
https://www.ncbi.nlm.nih.gov/pubmed/29403790
http://dx.doi.org/10.1016/j.jpha.2012.10.006

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