Validated LC–MS/MS method for simultaneous determination of SIM and its acid form in human plasma and cell lysate: Pharmacokinetic application

Simvastatin (SIM) is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor widely used in hyperlipidemia therapy. SIM has recently been studied for its anticancer activity at doses higher than those used for the hyperlipidemia therapy. This prompted us to study the pharmacokinetics of high-dos...

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Detalles Bibliográficos
Autores principales: Ahmed, Tamer A., Horn, Jamie, Hayslip, John, Leggas, Markos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760943/
https://www.ncbi.nlm.nih.gov/pubmed/29403775
http://dx.doi.org/10.1016/j.jpha.2012.07.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760943/
https://www.ncbi.nlm.nih.gov/pubmed/29403775
http://dx.doi.org/10.1016/j.jpha.2012.07.010

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