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A sensitive, simple and rapid HPLC–MS/MS method for simultaneous quantification of buprenorpine and its N-dealkylated metabolite norbuprenorphine in human plasma

A sensitive, simple and rapid high performance liquid chromatography-tandem mass spectrometry (HPLC–MS/MS) method was developed and fully validated for the simultaneous quantification of buprenorphine (BUP) and its N-dealkylated metabolite norbuprenorphine (NBUP) in 200 μL human plasma. Human plasma...

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Detalles Bibliográficos
Autores principales: Wang, Yi-Ya, Shen, Xiao-Hang, Li, Hao, Chen, Feng-Ju, Fu, Yan, Ding, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760959/
https://www.ncbi.nlm.nih.gov/pubmed/29403821
http://dx.doi.org/10.1016/j.jpha.2012.12.002