Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5'-methylcytosine at the end

Environmental factors stimulate alteration of DNA methylation level. Investigation of the genome-wide DNA methylation status is important for environmental health studies. We here designed a genomic DNA amplification and labeling protocol using a methylation-sensitive restriction enzyme HinP1 I. Thi...

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Detalles Bibliográficos
Autores principales: Kurita, Hisaka, Aiba, Toshiki, Saito, Toshiyuki, Ohsako, Seiichiroh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761092/
https://www.ncbi.nlm.nih.gov/pubmed/29339976
http://dx.doi.org/10.1186/s41021-017-0089-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761092/
https://www.ncbi.nlm.nih.gov/pubmed/29339976
http://dx.doi.org/10.1186/s41021-017-0089-5

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