An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes

An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 (CYP) enzymes. This method employed a cocktail of six probe substrates (i.e., phenacetin, amodiaquine, diclofenac, S-mephenytoin, dextromethorphan a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jing-Jing, Guo, Jian-Jun, Zhan, Jenny, Bu, Hai-Zhi, Lin, Jiunn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761213/
https://www.ncbi.nlm.nih.gov/pubmed/29403890
http://dx.doi.org/10.1016/j.jpha.2014.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761213/
https://www.ncbi.nlm.nih.gov/pubmed/29403890
http://dx.doi.org/10.1016/j.jpha.2014.01.001

Ejemplares similares