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An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes
An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 (CYP) enzymes. This method employed a cocktail of six probe substrates (i.e., phenacetin, amodiaquine, diclofenac, S-mephenytoin, dextromethorphan a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Xi'an Jiaotong University
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761213/ https://www.ncbi.nlm.nih.gov/pubmed/29403890 http://dx.doi.org/10.1016/j.jpha.2014.01.001 |