Simultaneous determination of ezetimibe and simvastatin in rat plasma by stable-isotope dilution LC-ESI–MS/MS and its application to a pharmacokinetic study

A simple, sensitive and specific liquid chromatography–tandem mass spectrometry method was developed for simultaneous quantification of ezetimibe and simvastatin in rat plasma. The deuterium isotopes: ezetimibe d(4) and simvastatin d(6) were used as internal standards for ezetimibe and simvastatin,...

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Detalles Bibliográficos
Autores principales: Karanam, Sireesha R., Katakam, Prakash, Chandu, Babu R., Hwisa, Nagiat T., Adiki, Shanta K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761217/
https://www.ncbi.nlm.nih.gov/pubmed/29403892
http://dx.doi.org/10.1016/j.jpha.2013.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761217/
https://www.ncbi.nlm.nih.gov/pubmed/29403892
http://dx.doi.org/10.1016/j.jpha.2013.08.002

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