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Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri
A furano-diterpene (polyalthic acid) was isolated as a major stable compound for the first time from the oleoresin of the Daniella oliveri of the family Caesalpiniacea through column chromatography fractionation. Polyalthic acid was characterized using data obtained from EIMS, HREIMS, ESI-MS, MALDI-...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Xi'an Jiaotong University
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761355/ https://www.ncbi.nlm.nih.gov/pubmed/29403907 http://dx.doi.org/10.1016/j.jpha.2014.05.002 |
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author | Atolani, Olubunmi Olatunji, Gabriel A. |
author_facet | Atolani, Olubunmi Olatunji, Gabriel A. |
author_sort | Atolani, Olubunmi |
collection | PubMed |
description | A furano-diterpene (polyalthic acid) was isolated as a major stable compound for the first time from the oleoresin of the Daniella oliveri of the family Caesalpiniacea through column chromatography fractionation. Polyalthic acid was characterized using data obtained from EIMS, HREIMS, ESI-MS, MALDI-MS as well as 1D and 2D NMR and it was evaluated for its potential to inhibit the formation of advanced glycation end-products (AGEs) using a standard in vitro antiglycation procedure. Polyalthic acid indicated a negative antiglycation potential compared to standard inhibitor that has 85% inhibition, which is an indication that polyalthic acid may not contribute to the antiglycation activity of the plant as acclaimed in folkloric medicine. The negative antiglycation observed could indicate that the polyalthic acid could trigger glycation, thereby subjecting users to various degrees of complications. The bioactivity evaluation on molinspiration evaluator indicated that polyalthic acid could be a potential drug candidate. The biological and chemical insights gained on polyalthic acid provide a good basis for future research. |
format | Online Article Text |
id | pubmed-5761355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Xi'an Jiaotong University |
record_format | MEDLINE/PubMed |
spelling | pubmed-57613552018-02-05 Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri Atolani, Olubunmi Olatunji, Gabriel A. J Pharm Anal Short Communication A furano-diterpene (polyalthic acid) was isolated as a major stable compound for the first time from the oleoresin of the Daniella oliveri of the family Caesalpiniacea through column chromatography fractionation. Polyalthic acid was characterized using data obtained from EIMS, HREIMS, ESI-MS, MALDI-MS as well as 1D and 2D NMR and it was evaluated for its potential to inhibit the formation of advanced glycation end-products (AGEs) using a standard in vitro antiglycation procedure. Polyalthic acid indicated a negative antiglycation potential compared to standard inhibitor that has 85% inhibition, which is an indication that polyalthic acid may not contribute to the antiglycation activity of the plant as acclaimed in folkloric medicine. The negative antiglycation observed could indicate that the polyalthic acid could trigger glycation, thereby subjecting users to various degrees of complications. The bioactivity evaluation on molinspiration evaluator indicated that polyalthic acid could be a potential drug candidate. The biological and chemical insights gained on polyalthic acid provide a good basis for future research. Xi'an Jiaotong University 2014-12 2014-05-20 /pmc/articles/PMC5761355/ /pubmed/29403907 http://dx.doi.org/10.1016/j.jpha.2014.05.002 Text en © 2014 Xi’an Jiaotong University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Short Communication Atolani, Olubunmi Olatunji, Gabriel A. Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri |
title | Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri |
title_full | Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri |
title_fullStr | Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri |
title_full_unstemmed | Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri |
title_short | Isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from Daniella oliveri |
title_sort | isolation and evaluation of antiglycation potential of polyalthic acid (furano-terpene) from daniella oliveri |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761355/ https://www.ncbi.nlm.nih.gov/pubmed/29403907 http://dx.doi.org/10.1016/j.jpha.2014.05.002 |
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